Effect of intracerebroventricular a-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression
نویسندگان
چکیده
JULIE E. MCMINN, CHARLES W. WILKINSON, PETER J. HAVEL, STEPHEN C. WOODS, AND MICHAEL W. SCHWARTZ, Program in Nutritional Sciences, Departments of Psychiatry and Behavioral Sciences and Medicine, University of Washington, Seattle 98195, Puget Sound Veterans Affairs Health Care System, Seattle 98108, Harborview Medical Center, Seattle, Washington 98104; Department of Nutrition, University of California at Davis, Davis, California 95616; and Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45267
منابع مشابه
Effect of intracerebroventricular alpha-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression.
alpha-Melanocyte-stimulating hormone (alpha-MSH) is a hypothalamic neuropeptide proposed to play a key role in energy homeostasis. To investigate the behavioral, metabolic, and hypothalamic responses to chronic central alpha-MSH administration, alpha-MSH was infused continuously into the third cerebral ventricle of rats for 6 days. Chronic alpha-MSH infusion reduced cumulative food intake by 10...
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Neuropeptide Y (NPY) is one of the important endogenous orexigenic peptides. In these studies we employed c-Fos immunostaining and a selective NPY Y1 receptor antagonist to identify the site of action of NPY in the hypothalamus. The results showed that intracerebroventricular administration of NPY stimulated feeding and increased immunostaining of c-Fos, a product of the immediate early gene c-...
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تاریخ انتشار 2000